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Alomone Labs, LTD
Kir7.1 (extracellular) Polyclonal Antibody
FIGURE: 1 / 3
Kir7.1 (extracellular) Antibody (APC-125-200UL) in IHC (P)
Expression of Kir7.1 in rat kidney - Immunohistochemical staining of paraffin embedded section of rat kidney using Anti-Kir7.1 (extracellular) Antibody (#APC-125), (1:100). Staining is present in both distal (DT) and proximal (PT) tubules and in the collecting ducts (CD) in the renal cortex. Note that staining is absent both inglomeruli (Gl) and blood vessels (arrow). Hematoxilin is used as the counterstain... View More
Product Details
APC-125-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)EMNGDLEIDHDVPPE, corresponding to amino acid residues 80-94 of rat KCNJ13, Extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inward rectifier K(+) channel Kir7.1; Inward rectifier potassium channel 13; kcnj13; Potassium channel, inwardly rectifying subfamily J member 13; potassium channel, inwardly rectifying subfamily J, member 13; potassium inwardly-rectifying channel, subfamily J, member 13
Gene Aliases: KCNJ13; KIR1.4; KIR7.1; LCA16; SVD
UniProt ID: (Human) O60928, (Rat) O70617, (Mouse) P86046
Entrez Gene ID: (Human) 3769, (Rat) 94341, (Mouse) 100040591
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