MA5-17113 targets LRP5 in FACS, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17113 immunogen is purified recombinant fragment of human LRP5 expressed in E. Coli.
MA5-17113 detects LRP5 which has a predicted molecular weight of approximately 179kDa.
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
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Protein Aliases: low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7
Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2
UniProt ID: (Human) O75197
Entrez Gene ID: (Human) 4041