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This antibody is a monoclonal mixture of FITC-conjugated CD4 (clone 7E14, isotype IgG1) and PE-conjugated CD26 (clone EUG-6, isotype IgG2a).
The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. CD26 [also known as dipeptidyl peptidase IV (DPP IV), adenosine deaminase (ADA) binding protein]. 1 - 3 is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti CD3-induced IL - 2 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADABP; ADCP-2; Adenosine deaminase complexing protein 2; CD26; CD4; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidyl-peptidase 4; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; T-cell activation antigen CD26; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; TP103
Gene Aliases: ADABP; ADCP2; CD26; CD4; CD4mut; DPP4; DPPIV; TP103
UniProt ID: (Human) P01730, (Human) P27487
Entrez Gene ID: (Human) 920, (Human) 1803
Molecular Function: serine protease
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