Positive Control: U87-MG, SK-N-SH, IMR32
Predicted Reactivity: Mouse (100%), Zebrafish (85%), Xenopus laevis (93%), Pig (100%), Chicken (96%), Rhesus Monkey (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
ENY2 is a component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: enhancer of yellow 2 homolog; Enhancer of yellow 2 transcription factor homolog; ENY2; Transcription and mRNA export factor ENY2
Gene Aliases: DC6; e(y)2; ENY2; Sus1
UniProt ID: (Human) Q9NPA8