Immunogen sequence: RLLLYHTHLR PRPRAYYLEP LPLPPEDEEP PAPTLLEPEK KAPEPPKTDK PGAAPPSTEE RKKKSTKGKK RSQPATKTED YGMGPGRSGP YGVTVPPDLL HHPNPGSITH LNYRQGSIGL YTQNQ
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
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Protein Aliases: Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; human opposite paired; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; mediator of RNA polymerase II transcription, subunit 12 homolog; OPA-containing protein; putative mediator subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; thyroid hormone receptor-associated protein, 230 kDa subunit; Trap230; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); Trinucleotide repeat-containing gene 11 protein
Gene Aliases: ARC240; CAGH45; FGS1; HOPA; KIAA0192; MED12; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
UniProt ID: (Human) Q93074
Entrez Gene ID: (Human) 9968