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Invitrogen
This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1 µg/mL | View 2 publications 2 publications |
Immunocytochemistry (ICC/IF) |
2-4 µg/mL | View 1 publication 1 publication |
Immunoprecipitation (IP) |
2-5 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Dog, Human, Mouse, Non-human primate, Rat, Xenopus |
Published species |
Human, Mouse |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
3D9 |
Immunogen |
Purified MEK from human T cells and recombinant MEK1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.4 |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2533012 |
MEK1/mitogen activated protein kinase/ERK kinase 1/microtubule-associated protein 2 kinase is a dual specificity kinase and catalyzes both a threonine and a tyrosine residue on MAP kinases ERK1 and ERK2. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dual specificity mitogen activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2); MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK1; mitogen activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; MKK (Thr292); MKK (Thr386); MKK2; MP2K1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Gene Aliases: CFC3; MAP2K1; MAPKK1; mek-2; MEK1; MEKK1; MKK1; PRKMK1; XELAEV_18018447mg
UniProt ID: (Human) Q02750, (Mouse) P31938, (Rat) Q01986, (Xenopus) Q05116
Entrez Gene ID: (Dog) 478347, (Human) 5604, (Mouse) 26395, (Rat) 170851, (Xenopus) 379991
Molecular Function:
non-receptor serine/threonine protein kinase
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