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PA5-34894 targets MTNR1A in WB applications and shows reactivity with Human samples.
The PA5-34894 immunogen is recombinant fragment corresponding to a region within amino acids 2 and 346 of Melatonin Receptor 1A (Uniprot ID#P48039).
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mel-1A-R; mel1a receptor; Melatonin receptor type 1A
Gene Aliases: MTNR1A
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