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Product Details
PA1-32563
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MT2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1957498
Product Specific Information
PA1-32563 detects Melatonin Receptor Type 1B (MT2) from human samples.
Target Information
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mel-1B-R; mel1b receptor; melatonin receptor 1B variant b; melatonin receptor MEL1B; Melatonin receptor type 1B
Gene Aliases: FGQTL2; MEL-1B-R; MT2; MTNR1B
UniProt ID: (Human) P49286
Entrez Gene ID: (Human) 4544
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
circadian rhythm
negative regulation of cGMP metabolic process
glucose homeostasis
camera-type eye development
negative regulation of neuron apoptotic process
positive regulation of vasodilation
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
regulation of insulin secretion
negative regulation of cytosolic calcium ion concentration
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
regulation of neuronal action potential
negative regulation of delayed rectifier potassium channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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