MA5-11486 targets Myogenin in GS, IF, IHC (P), IP, and WB applications and shows reactivity with Feline, Human, mouse, and Rat samples.
The MA5-11486 immunogen is recombinant protein containing rat myogenin aa 30-224.
Myogenin is a member of a family of myogenic regulatory genes, which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors, which are essential for muscle development. Transfection of myogenin into multipotential mesodermal cells have been shown to convert the mesodermal cells to myoblasts. Expression of myogenin is restricted to cells of skeletal muscle origin. It is therefore a useful marker for tumors of the muscle lineage, being strongly expressed in alveolar rhabdomyosarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHc3; Class C basic helix-loop-helix protein 3; Myf-4; MYOD1-related protein; Myogenic factor 4; Myogenic factor-4; Myogenin
Gene Aliases: BHLHC3; myf-4; MYF4; myo; MYOG