Invitrogen
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human N-Cadherin. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.15 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7, with 20% glycerol, 1% BSA |
Contains |
0.025% ProClin 300 |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2792635 |
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Chicken (100%), Bovine (100%).
Positive Control: 293T, NT2D1, SK-N-SH, mouse brain, rat brain, A549.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin
Gene Aliases: CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD
UniProt ID: (Human) P19022, (Mouse) P15116, (Rat) Q9Z1Y3
Entrez Gene ID: (Human) 1000, (Mouse) 12558, (Rat) 83501
Molecular Function:
cadherin
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