Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 7 publications 7 publications |
Immunohistochemistry (IHC) |
1:200-1:1,000 | - |
Immunocytochemistry (ICC/IF) |
1:200-1:1,000 | - |
Flow Cytometry (Flow) |
1/200 - 1/400 | - |
ELISA (ELISA) |
1:10,000 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Rat |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
5D5 |
Immunogen |
Purified recombinant fragment of human CDH2 expressed in E. Coli. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
Conc. Not Determined |
Storage buffer |
ascites |
Contains |
0.03% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_10985437 |
MA5-15633 targets CDH2 in FACS, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-15633 immunogen is purified recombinant fragment of human CDH2 expressed in E. Coli.
MA5-15633 detects CDH2 which has a predicted molecular weight of approximately 99.8kDa.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin
Gene Aliases: CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD
UniProt ID: (Human) P19022, (Mouse) P15116, (Rat) Q9Z1Y3
Entrez Gene ID: (Human) 1000, (Mouse) 12558, (Rat) 83501
Molecular Function:
cadherin
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