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Alomone Labs, LTD

NRG1 Type III (extracellular) Polyclonal Antibody

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NRG1 Type III (extracellular) Polyclonal Antibody

Product Details

ANR-113-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)DKIFEYDSPTHLD, corresponding to amino acid residues 101-113 of human Neuregulin-1 Type III, Extracellular
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL once reconstituted

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal development, migration, myelination, and synaptic maintenance. The expression of NRG1 type III expression have been studied in the adult brain, the medial prefrontal cortex, ventral hippocampus, and ventral subiculum. Expression of NRG1 type III expressio in these regions are involved in the regulation of sensorimotor gating and short-term memory.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; ErbB4 ligand; glial growth factor; glial growth factor 2; growth and differentiation factor splice variant; growth factor; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); III Type NRG1; neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; Neuregulin-1 Type III; NRG-1 Type III; NRG1; NRG1 Type 3; pro-NRG1; sensory and motor neuron derived factor; sensory and motor neuron-derived factor splice variant; SMDF; splice variant of neuregulin family of growth and differentiation factors; type I; type I neuregulin 1; type II membrane protein; type III neuregulin 1; unnamed protein product

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Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1-IT2; Pro-NRG1; SMDF

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UniProt ID: (Human) Q02297, (Mouse) Q6DR98

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Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323

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Function(s)
transcription cofactor activity receptor binding cytokine activity integrin binding protein binding growth factor activity zinc ion binding nickel cation binding protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity receptor agonist activity ErbB-2 class receptor binding
Process(es)
ventricular trabecula myocardium morphogenesis cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development brain development peripheral nervous system development cell proliferation positive regulation of cell proliferation regulation of cell communication negative regulation of cardiac muscle cell apoptotic process neural crest cell development regulation of signaling cell differentiation positive regulation of cell growth mammary gland development positive regulation of protein complex assembly activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB3 signaling pathway ERBB4 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway wound healing positive regulation of cell adhesion negative regulation of transcription, DNA-templated negative chemotaxis negative regulation of secretion positive regulation of developmental process positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of postsynaptic neurotransmitter receptor internalization positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade cell morphogenesis cardiac conduction system development response to stress synapse assembly heart development muscle organ development neuromuscular junction development female pregnancy memory locomotory behavior glial cell differentiation positive regulation of Schwann cell proliferation positive regulation of gene expression cardiac muscle cell apoptotic process positive regulation of neuron projection development Schwann cell development response to muscle activity cell migration sensory perception of pain glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex myelination in peripheral nervous system response to nutrient levels response to progesterone response to vitamin D multicellular organismal response to stress cellular response to potassium ion negative regulation of protein catabolic process myelination regulation of cell differentiation positive regulation of protein kinase activity positive regulation of JNK cascade positive regulation of Ras protein signal transduction neuron fate commitment positive regulation of axon regeneration oligodendrocyte differentiation cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation detection of temperature stimulus involved in sensory perception of pain positive regulation of protein kinase B signaling positive regulation of calcineurin-NFAT signaling cascade cellular response to mechanical stimulus response to dexamethasone postsynapse to nucleus signaling pathway synaptic membrane adhesion cellular response to serotonin cellular response to ciliary neurotrophic factor cellular response to acetylcholine cellular response to L-glutamate regulation of presynapse assembly positive regulation of membrane permeability cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus positive regulation of neural precursor cell proliferation negative regulation of corticosterone secretion negative regulation of neuron migration protein-containing complex disassembly
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