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Alomone Labs, LTD

Neurexin 1 alpha (extracellular) Polyclonal Antibody

View all (27) NRXN1 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

ANR-031-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:400
-

Immunocytochemistry (ICC/IF)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 of rat Nrxn1 alpha, Extracellular, N-terminus
View immunogen

Conjugate

Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Reconstitution: 1 X 25 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-latrotoxin receptor (calcium-dependent); DKFZp313P2036; FLJ35941; neurexin 1; Neurexin 1alpha; neurexin I; Neurexin I-alpha; Neurexin I-beta; Neurexin-1; Neurexin-1-alpha; Neurexin-1-beta; non-processed neurexin I-alpha

Gene Aliases: 1700062G21Rik; 9330127H16Rik; A230068P09Rik; Hs.22998; KIAA0578; mKIAA0578; NRXN1; Nrxn1b; PTHSL2; SCZD17

UniProt ID: (Human) Q9ULB1, (Mouse) Q9CS84, (Rat) Q63372

Entrez Gene ID: (Human) 9378, (Mouse) 18189, (Rat) 60391

Function(s)
vesicle docking involved in exocytosis cell adhesion signal transduction chemical synaptic transmission neurotransmitter secretion synapse assembly learning adult behavior social behavior vocal learning neuromuscular process controlling balance protein heterotetramerization positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic prepulse inhibition regulation of insulin secretion involved in cellular response to glucose stimulus vocalization behavior positive regulation of synapse maturation postsynaptic membrane assembly gephyrin clustering involved in postsynaptic density assembly neuroligin clustering involved in postsynaptic membrane assembly postsynaptic density protein 95 clustering positive regulation of excitatory postsynaptic potential regulation of grooming behavior angiogenesis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cerebellar granule cell differentiation protein localization to synapse establishment of protein localization negative regulation of filopodium assembly positive regulation of establishment of protein localization to plasma membrane protein complex assembly involved in synapse maturation synaptic vesicle clustering presynaptic membrane assembly gamma-aminobutyric acid receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering receptor localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity axon guidance
Process(es)
receptor activity calcium channel regulator activity calcium ion binding protein binding acetylcholine receptor binding cell adhesion molecule binding neuroligin family protein binding transmembrane signaling receptor activity receptor binding metal ion binding calcium-dependent protein binding
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