Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
NKX2-5 is a transcription factor protein which plays a crucial role in cardiac development and differentiation. It is a low molecular weight protein of 35-38 kDa depending on phosphorylation status. Expression is mainly restricted to the heart. But during embryogenesis NKX2-5 expression has also been detected in spleen-precursor cells. Over expression of NKX2-5 resulted in expression of neuronal markers in C2C12 murine myogenic cells. Functionally it is involved in differentiation processes in heart development and in homeostasis and survival of cardiac myocytes as well maintains the initial muscle differentiation paradigm.
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Protein Aliases: Cardiac-specific homeobox; cardiac-specific homeobox 1; CHNG5; CSX; CSX1; HLHS2; Homeobox protein CSX; Homeobox protein NK-2 homolog E; homeobox protein NKX 2-5; Homeobox protein Nkx-2.5; locus 5; NK2 transcription factor related; NK2 transcription factor related locus 5; NK2 transcription factor related, locus 5; NKX 2-5; NKX2.5; NKX2E; NKX4-1; tinman paralog; VSD3
Gene Aliases: CHNG5; CSX; CSX1; HLHS2; NKX2-5; NKX2.5; NKX2E; NKX4-1; VSD3
UniProt ID: (Human) P52952
Entrez Gene ID: (Human) 1482