MA3-935 detects OATP8 from human tissue and cells. This antibody does not detect dog, mouse or rat protein. MA3-935 also detects the OATP2 isoform.
MA3-935 has been successfully used in immunohistochemistry, immunofluorescence and immunoprecipitation procedures. Immunofluorescence staining of OATP8 in human liver samples results in a pattern consistent with plasma membrane staining.
The MA3-935 immunogen is a synthetic peptide corresponding ot residues M(1) D Q N Q H L N K T A E A Q P S E N K K T R Y(23) C of human OATP2.
The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Liver-specific organic anion transporter 1; Liver-specific organic anion transporter 2; liver-specific organic anion transporter 3TM13; LST-1; LST-2; OATP-2; OATP-8; OATP-C; Organic anion transporter 8; organic anion transporter LST-3c; Organic anion-transporting polypeptide 8; Sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 6; solute carrier family 21 (organic anion transporter), member 8; Solute carrier family 21 member 6; Solute carrier family 21 member 8; Solute carrier organic anion transporter family member 1B1; Solute carrier organic anion transporter family member 1B3; solute carrier organic anion transporter family, member 1B1; solute carrier organic anion transporter family, member 1B3
Gene Aliases: HBLRR; LST-1; LST-2; LST-3TM13; LST1; LST2; LST3; OATP-8; OATP-C; OATP1B1; OATP1B3; OATP2; OATP8; OATPC; SLC21A6; SLC21A8; SLCO1B1; SLCO1B3
Molecular Function: transporter