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Product Details
PA5-75631
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human OAZ3.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2719359
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The antizyme family is a group of small proteins that play a role in cell growth and division by regulating the biosynthesis of polyamines such as putrescine, spermidine and spermine. AZ3, also known as OAZ3 (Ornithine decarboxylase antizyme 3), is a 187 amino acid protein that belongs to the ODC antizyme family. AZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells because it binds to, and destabilizes, ornithine decarboxylase. However, mutations in the AZ3 gene are not a common cause of male infertility and the normal AZ3 protein does not accelerate ornithine decarboxylase degeneration. AZ3 expression has a sharp onset in early spermatids, peaks in later stages and is gone in spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antizyme 3; AZ3; OAZ-t; ODC-Az 3; Ornithine decarboxylase antizyme 3; testicular secretory protein Li 31; testis specific ornithine decarboxylase antizyme
Gene Aliases: Az-3; AZ3; OAZ-t; OAZ3; ODC-Az 3; TISP15
UniProt ID: (Human) Q9UMX2, (Mouse) Q9R109, (Rat) A1BPI0
Entrez Gene ID: (Human) 51686, (Mouse) 53814, (Rat) 689588
Molecular Function:
protein-binding activity modulator
regulation of cellular amino acid metabolic process
polyamine biosynthetic process
spermatogenesis
putrescine transport
negative regulation of catalytic activity
positive regulation of protein catabolic process
negative regulation of polyamine transmembrane transport
polyamine metabolic process
regulation of phosphoprotein phosphatase activity
ammonium transmembrane transport
positive regulation of intracellular protein transport
polyamine transmembrane transport
cation transmembrane transport
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