Keep as concentrated solution.
Positive Control: NT2D1, human ESC, HeLa transfected recombinant OCT3/4 protein.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Oct4 is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. Oct4 is one of the four Yamaka factors, necessary for embryonic stem cell pluripotency. Pluripotent stem (iPS) cells, can be created by expressing Oct4 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Oct4, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: class 5; MGC22487 antibody; Oct-3; Oct-4; Octamer-binding protein 3; octamer-binding protein 3 antibody; Octamer-binding protein 4; octamer-binding protein 4 antibody; Octamer-binding transcription factor 3; octamer-binding transcription factor 3 antibody; octamer-binding transcription factor-3 antibody; OTF-3; OTF-3 antibody; OTF3 antibody; OTF4 antibody; POU class 5 homeobox 1 antibody; POU class 5 homeobox 1 transcript variant OCT4B1; POU class 5 homeobox 1 transcript variant OCT4B2; POU class 5 homeobox 1 transcript variant OCT4B3; POU class 5 homeobox 1 transcript variant OCT4B4; POU class 5 homeobox 1 transcript variant OCT4B5; POU class 5 homeobox 1 transcript variant OCT4B6; POU domain; POU domain class 5 transcription factor 1; POU domain transcription factor OCT4; POU domain transcription factor OCT4 antibody; POU domain, class 5, transcription factor 1; POU-type homeodomain-containing DNA-binding protein; POU-type homeodomain-containing DNA-binding protein antibody; POU5F1 antibody; transcription factor 1 antibody
Gene Aliases: Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4; POU5F1
UniProt ID: (Human) Q01860
Entrez Gene ID: (Human) 5460