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FIGURE: 1 / 1
Positive test controls include: A-549, A-431, Jurkat, Mouse lung, Rat lung, Rat liver. The target is usually found in the following locations: Membrane, Single-pass type II membrane protein.
Immunogen sequence: TISDVKTNVQ LLKGRVDNIS TLDSEIKKNS DGMEAAGVQI QMVNESLGYV RSQFLKLKTS VEKANAQIQI LTRSWEEVST LNAQIPELKS DLEKASALNT KIRALQGSLE NMSKLLKRQN DILQVVSQGW K
Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD 207 antigen; CD207; CD207 antigen, langerin; CD207 molecule, langerin; Langerhans cell specific c-type lectin; Langerin
Gene Aliases: CD207; CLEC4K; RGD1565913
UniProt ID: (Human) Q9UJ71, (Mouse) Q8VBX4
Entrez Gene ID: (Human) 50489, (Rat) 502852, (Mouse) 246278
Molecular Function: membrane traffic protein
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