Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Membrane-associated progesterone receptor component 2; progesterone membrane binding protein; Progesterone membrane-binding protein; Steroid receptor protein DG6
Gene Aliases: DG6; PGRMC2; PMBP
UniProt ID: (Human) O15173
Entrez Gene ID: (Human) 10424
Molecular Function: transmembrane signal receptor
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