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Immunogen sequence: HSVSESPGKT VTISCTRSSG SIASNYVQWY QQRPGSAPTT VIYEDNQRPS GVPDRFSGSI DSSSNSASLT ISGLKTEDEA DYYCQSYDSS NHTVL
Antigen sequence identity: Mouse 47%; Rat 65%
IGLV6-57 (Immunoglobulin Lambda Variable 6-57) is a Protein Coding gene. An important paralog of this gene is IGLV1-40. V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IGLV657; V1-22
Gene Aliases: IGLV657; V1-22
Entrez Gene ID: (Human) 28778
Molecular Function: immunoglobulin
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