Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains that collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery. At least four isoforms of SCARB1 are known to exist.
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Protein Aliases: Scavenger receptor class A member 5; scavenger receptor class A, member 5 (putative); Scavenger receptor hlg; testis expressed scavenger receptor
Gene Aliases: 4932433F15Rik; 4933425F03Rik; AV278087; NET33; SCARA5; Tesr; UNQ2938/PRO28700