The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
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Protein Aliases: Bruton agammaglobulinemia tyrosine kinase inhibitor; BTK-binding protein; BTKI; IBtk; Inhibitor of Bruton tyrosine kinase; inhibitor of Bruton's; inhibitor of Bruton's tyrosine kinase; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma; RP1-93K22.1
Gene Aliases: BTBD26; BTKI; IBTK; KIAA1417
UniProt ID: (Human) Q9P2D0
Entrez Gene ID: (Human) 25998