Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: 293T, Jurkat.
Predicted reactivity: Human (99%), Mouse (95%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are considered important components of the extracellular matrix. The extracellular matrix plays an integral role in the pivotal processes of development, tissue repair and metastasis by regulating cell proliferation, differentiation, adhesion and migration. Podocan, also known as PCAN, SLRR5A or PODN, is a 613 amino acid secreted protein belonging to the small leucine-rich proteoglycan (SLRP) family and the class V subfamily. Expressed in kidney, heart, liver, pancreas and vascular smooth muscle cells, Podocan exists as three alternatively spliced isoforms containing twenty LRR (leucine-rich repeats), a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. Podocan is considered a glycoprotein containing N-linked oligosaccharides that may be involved in growth regulation in cardiovascular tissues. Encoded by a gene located on human chromosome 1, Podocan interacts type I collagen (COL1).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Podocan; podocan proteoglycan; PRO332; UNQ293
Gene Aliases: PCAN; PODN; SLRR5A; UNQ293/PRO332
UniProt ID: (Human) Q7Z5L7
Entrez Gene ID: (Human) 127435
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support