Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Monkey, Marmoset (88%).
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
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Protein Aliases: CEPR; Chemoattractant receptor-like 2; Chemokine receptor-like 2; CMKRL2; constitutively expressed peptide-like receptor; DRY12; FEG-1; Flow-induced endothelial G-protein coupled receptor 1; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; GPER; GPR30; Heptahelix receptor; IL8-related receptor DRY12; LERGU; LERGU2; leucine rich protein in GPR30 3'UTR; LYGPR; Lymphocyte-derived G-protein coupled receptor; Membrane estrogen receptor; MER
Gene Aliases: CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPER1; GPR30; LERGU; LERGU2; LyGPR; mER
UniProt ID: (Human) Q99527
Entrez Gene ID: (Human) 2852