Peptide sequence: EEVALRATAE NEFVALKKDV DCAYLRKSDL EANVEALIQE IDFLRRLYEE
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 91%; Pig: 93%; Rabbit: 86%; Rat: 93%
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex.
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Protein Aliases: Hair keratin K2.10; hard keratin, type II, 3; hHb3; K83; keratin 81; keratin 83; keratin 83, type II; keratin 84; keratin complex 2, basic, gene 25; keratin type II; keratin, hair, basic, 3; Keratin, type II cuticular Hb3; Keratin-83; type II hair keratin; Type II hair keratin Hb3; Type-II keratin Kb23
Gene Aliases: BOS_5044; Hb-3; HB3; K83; Keratin-83; KRT81; KRT83; KRTHB3