Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: DSLNSDCLTS FKITDLGKIN YSSEPSDCNE DDLFEDKQEN RYLVVPPLET GLKVCFSSFR ELRQHLLLKE KIISKSYKAL INLVQGKDDN TSSAEEKECL VPLCGEEENS VHILDEKLSD NFQDSEQLVE KIWY
Highest antigen sequence identity to the following orthologs: Mouse - 47%, Rat - 46%.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein.
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Protein Aliases: FAAP95; Fanconi anemia group B protein; Fanconi anemia-associated polypeptide of 95 kDa; FLJ34064; Protein FACB
Gene Aliases: FA2; FAAP90; FAAP95; FAB; FACB; FANCB
UniProt ID: (Human) Q8NB91
Entrez Gene ID: (Human) 2187
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