Immunogen sequence: KGDRKSTGLK LSKKKARRRH TDDPSKECFT LKFDLNVDIE TEIVPAMKKK SLGEVLLPVF ERKGIALGKV DIYLDQSNTP LSL
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.
Protein Aliases: GEF720; Guanine nucleotide exchange factor 720; KIAA0720; NFkB activating protein; novel PH domain-containing protein; PH domain-containing family G member 5; pleckstrin homology domain containing family G member 5; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; Pleckstrin homology domain-containing family G member 5; PLEKHG5; synectin-binding guanine exchange factor
Gene Aliases: CMTRIC; DSMA4; GEF720; KIAA0720; PLEKHG5; Syx; Tech
UniProt ID: (Human) O94827
Entrez Gene ID: (Human) 57449