This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PSACLKLFQE KKEEGYGEAA QFDGLKHQAK RSINEMLADR HLQRDNLHAQ KCIDWN\r
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hPAD-colony 10; PADI5; PDI2; PDI3; PDI4; peptidyl arginine deiminase, type I; Peptidylarginine deiminase I; Protein-arginine deiminase type I; Protein-arginine deiminase type-1
Gene Aliases: HPAD10; PAD1; PADI1; PDI; PDI1
UniProt ID: (Human) Q9ULC6
Entrez Gene ID: (Human) 29943
Molecular Function: hydrolase