Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: QVSQQLQQTN RVLEVTNSSL RQQLRLKITQ LGQSAEDLQG SRRELAQSQE ALQVEQRAHQ AAEGQLQACQ ADRQKTKETL QSEEQQRRAL EQKLSNMENR LKPFFTCGSA DTCCPSGWIM HQKSCFYISL TSKNWQESQK QCETLSSKLA TFSEIYPQSH SYYFLNSLLP NGGSGNSYWT GLSSNKDWKL TDDTQRTRTY AQSSKCNKVH KTWSWWTLES ESCRSSLPYI CEMTAFRFPD; Positive Samples: B-cell, Mouse liver, Mouse kidney, Rat liver, Rat kidney; Cellular Location: Membrane, Single-pass type II membrane protein
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
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Protein Aliases: B-cell differentiation antigen CD72; CD72; CD72 antigen; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
Gene Aliases: CD72; CD72b; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2; LYB2
UniProt ID: (Human) P21854, (Mouse) P21855
Entrez Gene ID: (Human) 971, (Rat) 313498, (Mouse) 12517
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