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Immunogen sequence: EEMEKESGPG QKRPNKQEES ESPVERPLKE NPPNKMTQEK LEESSTIGQD QTLMERDTEG GAAEINCNGV IEVINYTQNS NNETLRHKED LHNANDCDVQ NLNQESSFLS SQNGDSSTSQ ETDSCTPITS EVSDTMVCQS SSTVGQSFSE QHISQLQESI RAEIPCEDEQ EQEHNGPLDN KGKSTAGNFL V; Positive Samples: 293T, HepG2, MCF7, HeLa, THP-1 ; Cellular Location: Cytoplasm, Microsome, Microsome, Nucleus, Nucleus matrix
SRPK1 is a serine/threonine kinase that plays a role in the regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. SRPK1 localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.
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