This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalization, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localization in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of ~87 kDa.
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Protein Aliases: plakophilin 3b; Plakophilin-3
Gene Aliases: PKP3
UniProt ID: (Human) Q9Y446
Entrez Gene ID: (Human) 11187