The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4.
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Protein Aliases: Amidophosphoribosyltransferase; ATase; EC 126.96.36.199; glutamine phosphoribosylpyrophosphatate amidotransferase; Glutamine phosphoribosylpyrophosphate amidotransferase; glutamine PRPP amidotransferase; GPAT
Gene Aliases: ATASE; GPAT; PPAT; PRAT
UniProt ID: (Human) Q06203
Entrez Gene ID: (Human) 5471
Molecular Function: transferase