Keep as concentrated solution.
Positive Control: Jurkat, Raji, K562, THP-1, HL-60, NCI-H929, rat kidney.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
PRMT5 (protein arginine N-methyltransferase 5) is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3; such methylation is required for the assembly and biogenesis of snRNP core particles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; Jak-binding protein 1; Protein arginine N-methyltransferase 5; Protein arginine N-methyltransferase 5, N-terminally processed; Shk1 kinase-binding protein 1 homolog; SKB1 homolog
Gene Aliases: HRMT1L5; IBP72; JBP1; PRMT5; SKB1; SKB1Hs
UniProt ID: (Human) O14744
Molecular Function: signaling molecule