Positive Control: A549, PC-12, NIH/3T3, SW620, rat large intestine tissue, human liver tissue, human breast tissue, human placenta tissue.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; proteasome (prosome, macropain) subunit, alpha type, 3; Proteasome component C8; Proteasome subunit alpha type-3; proteasome subunit C8; PSA3; testicular secretory protein Li 43
Gene Aliases: HC8; PSC3; PSC8; PSMA3
UniProt ID: (Human) P25788
Entrez Gene ID: (Human) 5684
Molecular Function: protease