PA1-4552 detects Parkin in human samples.
PA1-4552 has been successfully used in Western blotting and immunoprecipitation procedures. By Western blot, this antibody detects a ~52 kDa protein representing Parkin in HEK cells stably expressing the protein.
PA1-4552 immunizing peptide corresponds to an internal sequence of the 52 kDa Parkin human protein.
Maintain antibody at 4°C for up to 3 months. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Protein Aliases: E3 ubiquitin-protein ligase parkin; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; Parkin; parkin 2; Parkin isoform 1; Parkin RBR E3 ubiquitin-protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Gene Aliases: AR-JP; LPRS2; PARK2; PDJ; PRKN
UniProt ID: (Human) O60260
Entrez Gene ID: (Human) 5071
Molecular Function: ubiquitin-protein ligase