PA1-4552 detects Parkin in human samples.
PA1-4552 has been successfully used in Western blotting and immunoprecipitation procedures. By Western blot, this antibody detects a ~52 kDa protein representing Parkin in HEK cells stably expressing the protein.
PA1-4552 immunizing peptide corresponds to an internal sequence of the 52 kDa Parkin human protein.
Maintain antibody at 4°C for up to 3 months. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase parkin; Park2; Parkin; Parkin RBR E3 ubiquitin-protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin); Prkn; Ubiquitin E3 ligase PRKN
Gene Aliases: AR-JP; LPRS2; PARK2; PDJ; PRKN
UniProt ID: (Human) O60260
Entrez Gene ID: (Human) 5071