This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with Chk2 phosphorylated at other sites.
This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit. The antibody sold separately may have slightly different performance and may need to be further optimized for the best results.
Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cds1 homolog; Checkpoint kinase 2; checkpoint-like protein CHK2; CHK2 checkpoint homolog; Hucds1; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; protein kinase CHK2; Serine/threonine-protein kinase Chk2
Gene Aliases: CDS1; CHEK2; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
UniProt ID: (Human) O96017
Entrez Gene ID: (Human) 11200
Molecular Function: non-receptor serine/threonine protein kinase