Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
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Protein Aliases: Developmental kinase 2; Developmental kinase 5; EK2; EK6; ELK; ELK-related protein tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH-like kinase 2; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; Ephrin type-B receptor 1; Ephrin type-B receptor 3; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; human embryo kinase 2; mDK-2; mDK-5; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO6
Gene Aliases: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek6; EK2; ELK; Elkh; ENSMUSG00000074119; EPHB1; Ephb2; EPHB3; EPHB4; EPHT2; Epth2; Erk; ETK2; HEK2; HEK6; HTK; MDK2; MDK5; MYK1; NET; Sek4; TYRO11; TYRO6