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PA1-25983 detects Heat Shock Protein 27 (phospho S82) from human samples. PA1-25983 will not react with endogenous mouse Heat Shock Protein 27 protein phosphorylated on S86 (S86 in mouse is in a region identical to that surrounding S82 in human Heat Shock Protein 27) in extracts of NIH3T3 cells treate
PA1-25983 has been successfully used in Western blot procedures.
The PA1-25983 immunogen is a synthetic phosphopeptide corresponding to a portion of human Heat Shock Protein 27 containing threonine 232.
Store at 4°C short term. For extended storage, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state. It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 28 kDa heat shock protein; DKFZp586P1322; epididymis secretory protein Li 102; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; Heat shock protein beta-1; HS; HSP; HSP 27; HspB1; Phospho-HSP 27; SRP27; Stress-responsive protein 27
Gene Aliases: HSP27; HSP28; HSPB1
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