The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.
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Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; I kappa B kinase 1; I kappa-B kinase alpha, IkBKA, IKK-alpha, IKK-A, IkappaB kinase, EC 220.127.116.11, I-kappa-B kinase 1, IKK1, Conserved helix-loop-helix ubiquitous kinase, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA, CHUK, IKKA, TCF16, IKK-beta, IKK2, IKKB, NFKBIKB; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IkBKA; IkBKB; IKK alpha; IKK-A; IKK-a kinase; IKK-alpha; IKK-B; IKK-beta; IKK1; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; Transcription factor 16
Gene Aliases: AI132552; AI256658; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKBKB; IKK-2; IKK-alpha; IKK-beta; IKK1; IKK2; IKK[b]; IKKA; IKKB; IKKbeta; IMD15; NFKBIKA; NFKBIKB; TCF16