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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Hamster, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human IRS-1 that contains serine 307 (serine 302 in mouse sequence).|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 50% glycerol, 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm"e;s tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: IRS-1,2,3, and 4, with IRS-1 being widely expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice.||Yu XX,Murray SF,Watts L,Booten SL,Tokorcheck J,Monia BP,Bhanot S||American journal of physiology. Endocrinology and metabolism (295:E436)||2008|
|Hamster||Not Cited||Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.||Liu YF,Herschkovitz A,Boura-Halfon S,Ronen D,Paz K,Leroith D,Zick Y||Molecular and cellular biology (24:9668)||2004|
insulin receptor substrate 1; Insulin receptor substrate-1; IRS-1; IRS1; pp185
G972R; HIRS-1; IRS-1; IRS1; IRS1IRM