SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
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Protein Aliases: HGNC:11205; Specificity protein 1; trans-acting transcription factor 1; Transcription factor Sp1
Gene Aliases: 1110003E12Rik; AA450830; AI845540; SP1; Sp1-1; TSFP1
Molecular Function: C2H2 zinc finger transcription factor