Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor cells.
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Protein Aliases: DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; EC 220.127.116.11; OTTHUMP00000207108; P11388-1; topoisomerase (DNA) 2 alpha; topoisomerase (DNA) II alpha 170kDa; topoisomerase ii alpha
Gene Aliases: Top-2; TOP2; TOP2A; TP2A
Molecular Function: DNA metabolism protein