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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • p21 Antibodies
          The product (cat # {{productObj.productId}}) that you're looking for has been discontinued and replaced with {{productObj.replacementProductId}}. The product (cat # {{productObj.productId}}) that you're looking for has been discontinued. Please contact Technical Support with any questions.

          Invitrogen

          Phospho-p21 (Thr145) Polyclonal Antibody

          Advanced Verification
          1 Published Figure
          2 References
          View all (87) p21 antibodies

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          Datasheet
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          Datasheet
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          Cite Phospho-p21 (Thr145) Polyclonal Antibody

          • Antibody Testing Data (4)
          • Published Figures (1)
          • Advanced Verification (1)
          Phospho-p21 (Thr145) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Phospho-p21 (Thr145) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 6

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          Phospho-p21 (Thr145) Antibody (PA5-12646) in IHC (P)

          Immunohistochemistry analysis of Phospho-p21 (Thr145) in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with Phospho-p21 (Thr145) polyclonal antibody (Product # PA5-12646) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Phospho-p21 (Thr145) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-p21 (Thr145) Antibody in Western Blot (WB)
          Phospho-p21 (Thr145) Antibody in Western Blot (WB)
          Phospho-p21 (Thr145) Antibody in Dot Blot (DB)
          Phospho-p21 (Thr145) Antibody in Western Blot (WB)
          Phospho-p21 (Thr145) Antibody

          Product Details

          PA5-12646

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:100
          -

          Dot blot (DB)

          1:500
          -

          Miscellaneous PubMed (Misc)

          -
          View 1 publication 1 publication
          Product Specifications

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T145 of human P21CIP1
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.4 mg/mL

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10979470

          Target Information

          Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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