This protein is a key enzyme in catabolism of quinolinate. an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has be.
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Protein Aliases: epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating); Nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; QPRT; QPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]
Gene Aliases: HEL-S-90n; QPRT; QPRTase
UniProt ID: (Human) Q15274
Entrez Gene ID: (Human) 23475