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PA1-318 detects isoforms 1 and 2 of RUNX3 protein from human samples.
PA1-318 has been successfully used in Western blot applications. By western blot this antibody detects a doublet (bands at ~43 and 45 kDa) representing the two know isoforms of the RUNX3 protein from Raji nuclear extract.
The PA1-318 immunogen is a synthetic peptide corresponding to residues T(205) K P F P D R F G D L E R L R M R(221) of human RUNX3. The synthetic peptide (Cat. # PEP-292) can be purchased for use as a neutralizing agent.
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; CBF-alpha 3; CBF-alpha-3; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; Oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; Runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2
Gene Aliases: AML2; CBFA3; PEBP2A3; RUNX3
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