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Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2. form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999).
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Protein Aliases: activator of SUMO1; FLJ3091; sentrin/SUMO-activating protein AOS1; SUMO-1 activating enzyme E1 N subunit; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; Ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme
Gene Aliases: AOS1; HSPC140; SAE1; SUA1; UBLE1A
UniProt ID: (Human) Q9UBE0
Entrez Gene ID: (Human) 10055
Molecular Function: ubiquitin-protein ligase