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Product Details
MA5-25380
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
Assay-Dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Dog, Human, Non-human primate, Rat |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI3C2 |
Immunogen |
Full length human recombinant protein of SERPINB3 produced in HEK293T cell |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.64 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 1% BSA, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2725327 |
Target Information
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein T4-A; SCCA-1; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serine protease inhibitor B3; Serpin B3; serpin family B member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 4; spb3; Squamous cell carcinoma antigen 1
Gene Aliases: HsT1196; SCC; SCCA; SCCA-1; SCCA-PD; SCCA1; SERPINB3; SERPINB4; SSCA1; T4-A
UniProt ID: (Human) P29508
Entrez Gene ID: (Dog) 483954, (Human) 6317, (Rat) 304688
Molecular Function:
protease inhibitor
positive regulation of cell proliferation
negative regulation of peptidase activity
positive regulation of epithelial to mesenchymal transition
positive regulation of endopeptidase activity
negative regulation of endopeptidase activity
positive regulation of cell migration
autocrine signaling
paracrine signaling
negative regulation of catalytic activity
negative regulation of JUN kinase activity
negative regulation of proteolysis
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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