Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Sequence of this protein is as follows: MAESHLLQWL LLLLPTLCGP GTAAWTTSSL ACAQGPEFWC QSLEQALQCR ALGHCLQEVW GHVGADDLCQ ECEDIVHILN KMAKEAIFQD TMRKFLEQEC NVLPLKLLMP QCNQVLDDYF PLVIDYFQNQ TDSNGICMHL GLCKSRQPEP EQEPGMSDPL PKPLRDPLPD PLLDKLVLPV LPGALQARPG PHTQDLSEQQ FPIPLPYCWL CRALIKRIQA MIPKGALAVA VAQVCRVVPL VAGGICQCLA ERYSVILLDT LLGRMLPQLV CRLVLRCSMD DSAGPRSPTG EWLPRDSECH LCMSVTTQAG NSSEQAIPQA MLQACVGSWL DREKCKQFVE QHTPQLLTLV PRGWDAHTTC QALGVCGTMS SPLQCIHSPD L
Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.
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Protein Aliases: 18 kDa pulmonary-surfactant protein; 6 kDa protein; P SFTB3; Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SFPB; SP-B
Gene Aliases: PSP-B; SFTB3; SFTP3; SFTPB; SMDP1; SP-B
UniProt ID: (Human) P07988
Entrez Gene ID: (Human) 6439
Molecular Function: scaffold/adaptor protein
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