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Product Details
PA3-16805
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Extracellular residues 230-380 of Scavenger Receptor-BI/BII expressed as two tandem copies in bacteria using the pET system.
Conjugate
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2182692
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 1; CD36 antigen-like 2; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; LGP85; LIMP II; Lysosome membrane protein 2; Lysosome membrane protein II; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; Scavenger receptor class B member 2; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B, member 2; scavenger receptor class B1; SR-B1/B2; SR-BI; SR-BI/BII; SRB1
Gene Aliases: 9330185J12Rik; AI120173; AMRF; CD36; CD36L1; CD36L2; CLA-1; CLA1; D5Ertd460e; EPM4; Hdlq1; HDLQTL6; Hlb398; HLGP85; LGP85; LIMP-2; LIMP2; LIMPII; MLGP85; mSR-BI; SCARB1; SCARB2; SR-B1; SR-BI; SR-BII; SRB1; SRBI
UniProt ID: (Human) Q8WTV0, (Human) Q14108, (Rat) P97943, (Mouse) Q61009, (Rat) P27615, (Mouse) O35114
Entrez Gene ID: (Human) 949, (Human) 950, (Rat) 25073, (Mouse) 20778, (Rat) 117106, (Mouse) 12492
Molecular Function:
membrane trafficking regulatory protein
endothelial cell proliferation
androgen biosynthetic process
cholesterol catabolic process
receptor-mediated endocytosis
positive regulation of endothelial cell migration
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
wound healing
lipoprotein metabolic process
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
viral entry into host cell
regulation of phagocytosis
intestinal absorption
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
protein targeting to lysosome
steroid biosynthetic process
lipid transport
phagocytosis, recognition
cell adhesion
cholesterol transport
pattern recognition receptor signaling pathway
lipopolysaccharide binding
virus receptor activity
phosphatidylserine binding
lipopolysaccharide receptor activity
transporter activity
protein binding
1-phosphatidylinositol binding
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
protein homodimerization activity
high-density lipoprotein particle receptor activity
enzyme binding
lipid transporter activity
receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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