High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
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Protein Aliases: 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 1; CD36 antigen-like 2; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; LGP85; LIMP II; Lysosome membrane protein 2; Lysosome membrane protein II; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; Scavenger receptor class B member 2; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B, member 2; scavenger receptor class B1; SR-B1/B2; SR-BI; SR-BI/BII; SRB1
Gene Aliases: 9330185J12Rik; AI120173; AMRF; CD36; CD36L1; CD36L2; CLA-1; CLA1; D5Ertd460e; EPM4; Hdlq1; HDLQTL6; Hlb398; HLGP85; LGP85; LIMP-2; LIMP2; LIMPII; MLGP85; mSR-BI; SCARB1; SCARB2; SR-B1; SR-BI; SR-BII; SRB1; SRBI
Molecular Function: receptor