MA5-11685 targets SREBP-1 in WB applications and shows reactivity with Hamster and Human samples.
The MA5-11685 immunogen is recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1.
SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ~480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.
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Protein Aliases: bHLHd1; Class D basic helix-loop-helix protein 1; nt-SREBP1; Processed sterol regulatory element-binding protein 1; SREBP-1; sterol regulatory element binding protein-1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
Gene Aliases: BHLHD1; I79_010155; SREBF1; SREBP-1; SREBP-1c; SREBP1; SREBP1a